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Patients unable to take pyrazinamide or with tuberculosis due to strains of mycobacterium tuberculosis resistant to pyrazinamide should receive isoniazid daily or 5 times week in combination with rifampin and ethambutol for 2 months, then 7 additional months of isoniazid
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Speculation that fast acetylators of isoniazid could be at increased risk of hepatotoxicity due to production of a hepatotoxic hydrazine metabolite has not been supported; in fact, slow acetylators have generally been found to have a higher risk than fast
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The table below contains the most common ones associated with isoniazid.
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In addition to isoniazid, your doctor is likely to recommend that you avoid certain foods and drinks such as alcohol during the course of your treatment.