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Applies to estradiolcompounding powderintramuscular solutionoral tablettransdermal emulsiontransdermal film extended releasetransdermal geltransdermal sprayvaginal ring.
Exogenous estrogens are metabolized in the same manner as endogenous estrogensCirculating estrogens exist in a dynamic equilibrium of metabolic interconversionsThese transformations take place mainly in the liverEstradiol is converted reversibly to estroneand both can be converted to estriolwhich is the major urinary metaboliteEstrogens also undergo enterohepatic recirculation via sulfate and glucuronide conjugation in the liverbiliary secretion of conjugates into the intestineand hydrolysis in the gut followed by reabsorptionIn postmenopausal womena significant proportion of the circulating estrogens exist as sulfate conjugatesespecially estrone sulfatewhich serves as a circulating reservoir for the formation of more active estrogens.
If any of these warning signalsor any other unusual symptomshappen while you are using estrogenscall your doctor immediately:
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