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Patients should be advised of the signs and symptoms and monitored closely for skin reactionsThe highest risk for occurrence of SJS or TEN is within the first weeks of treatment.
Piroxicam is a potent inhibitor of prostaglandinPGsynthesis in vitroPiroxicam concentrations reached during therapy have produced in vivo effectsProstaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal modelsProstaglandins are mediators of inflammationBecause piroxicam is an inhibitor of prostaglandin synthesisits mode of action may be due to a decrease of prostaglandins in peripheral tissues.
NSAIDsincluding FELDENEmay increase the risk of bleeding eventsCo-morbid conditions such as coagulation disordersconcomitant use of warfarinother anticoagulantsantiplatelet agentse.gaspirinserotonin reuptake inhibitorsSSRIsand serotonin norepinephrine reuptake inhibitorsSNRIsmay increase this riskMonitor these patients for unisom available australia. signs of bleedingsee DRUG INTERACTIONS
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Cardiovascular Thrombotic Eventssee WARNINGS AND PRECAUTIONSGI BleedingUlceration and Perforationsee WARNINGS AND PRECAUTIONSHepatotoxicitysee WARNINGS AND PRECAUTIONSHypertensionsee WARNINGS AND PRECAUTIONSHeart Failure and Edemasee WARNINGS AND PRECAUTIONSRenal Toxicity and Hyperkalemiasee WARNINGS AND PRECAUTIONSAnaphylactic Reactionssee WARNINGS AND PRECAUTIONSSerious Skin Reactionssee WARNINGS AND PRECAUTIONSHematologic Toxicitysee WARNINGS AND PRECAUTIONS
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